Researchers develop nanoparticles that target multiple COVID variants: A breakthrough in fighting the virus

A team of researchers from the University of Michigan and Jiangnan University in Wuxi, China, have created nanoparticles that can fight against different strains of the SARS-CoV-2 virus.

This discovery has the potential to improve the efficacy of existing COVID-19 treatments. The results of the study were published in the Proceedings of the National Academy of Sciences journal.

Why need a new treatment? Current challenges with COVID-19 treatments

Despite being effective, mRNA vaccines do not give total protection from COVID-19 as it can still affect vaccinated individuals, especially the elderly. Emerging strains of the virus pose ongoing challenges, necessitating frequent updates to vaccines to maintain their efficacy. Professor Nicholas Kotov from the University of Michigan told Phys Org, "Our immune system needs time to generate antibodies, which may be too late for some people." While Pfizer's Paxlovid antiviral pill has shown promising results, it may not be suitable for all patients, particularly those with cardiovascular issues.

How do nanoparticles work against COVID variants?

The nanoparticles target the twist in spike proteins, known as chirality, allowing them to interact with various coronaviruses. The nanoparticles' left-handed twist matches the left-handed twist of virus proteins, enhancing their binding and reducing the ability of virus to infect cells.

How did nanoparticle treatment do in initial testing?

Tests on mice infected with different strains of pseudoviruses showed promising results, with the treatment clearing 95 per cent of the viruses from their lungs.

Researchers aim to investigate the safety and longevity of these nanoparticles in humans through further studies. Chinese Academy of Medical Sciences and Peking Union Medical College, as well as the Brazilian Centre for Research in Energy and Materials, were also a part of this research.

This study is a breakthrough in the field of medical science as it presents a promising avenue for combating COVID-19. With further research and enhancements, nanoparticles can contribute significantly to global efforts in managing and preventing the spread of COVID-19.

(With inputs from agencies)